Neurometabolic Lipid Research

Dr. Patricia Kane, PhD

Dr. Kane’s dedication and success in working with patients with fragile brain architecture has brought her widespread recognition in the field of biometabolic intervention by blending lipid bench science, medical lipid research with clinical medicine  by which she coined the term Membrane Medicine. She serves as Director of the NeuroLipid Research Foundation, a 501c3 nonprofit organization in Millville, New Jersey.  Her expertise in boldly addressing neurological disorders and lipid disturbance with targeted nutritional intervention for neurological disorders has led to direct biometabolic application utilized by physicians and researchers worldwide. Dr. Kane’s clinical experience,  working with physicians, spans 39 years.

Dr. Kane has pioneered targeted metabolic application of the red cell fatty acid analysis from Johns Hopkins Kennedy Krieger Institute’s Peroxisomal Diseases Laboratory over the past 21 years. Using basic blood chemistry / CBC she has been able to integrate biomedical interventions for both pediatric and adult populations with acute as well as chronic conditions.  In 2008, she applied a specialized epigenetic analysis ‘a portal into the cell’  whereby images of the membrane surface, phospholipids and mitochondria of each patient along with their DNA adducts were utilized to approach the patient’s epigenetic aberrations. After application of oral and intravenous bioactive lipid intervention, both improvement in the patients’ clinical status and normalization of the phospholipids per red cell analysis and membrane imaging. Dr. Kane’s work has expedited the incorporation of current research and  evidence based medicine directly into clinical practice to yield resolution of some of the complex medical disorders of our time.

Having a long standing interest in the challenging area of the treatment of neurological disease, Dr. Kane has approached refractory disorders: Alzheimer’s, Autistic Spectrum Disorders, Pervasive Developmental Delay, Seizure Disorders including refractory status epilepticus, Traumatic Brain Injury, Chronic Traumatic Encephalopathy, Inborn Errors in Metabolism/genetic disorders, Epigenetic insult, Neurotoxicity (Toxic and Viral Encephalopathy, Neurotoxic Fungal  exposure), Post Stroke, neuroinflammatory and autoimmune disorders, chronic infections including Neurolyme, psychiatric disorders, Multiple Sclerosis, Motor Neuron and Parkinson’s Disease. Dr. Kane developed an intravenous protocol, the Membrane Stabilizing PK Protocol using IV phospholipid therapy and oral fatty acid supplementation that has resulted in positive patient outcomes being utilized by thousands of physicians in the USA and internationally.

Present research studies include examination of red cell lipid aberrations, ceramides/ lipid rafts, and deformation in the phospholipid membranes in autism, MS, ALS, Parkinson’s and various inherited diseases. Oral and intravenous treatment protocols include targeted lipid therapy with lipid mediators phenylbutyrate, phosphatidylcholine, phosphatidylethanolamine, bioactive lipids and a membrane stabilizing (modified ketogenic) diet directed towards stabilization of cellular, organelle and myelin architecture to normalize organelle function to resolve the accumulation  aberrant proteins and lipids characteristic in neurological and orphan diseases.

Dr. Kane has published numerous articles, essays, book chapters and books focusing on evidence based medicine for over 39 years. She contributed  two chapters, 1) Seizure Disorders: Balancing Fatty Acids to Stabilize Brain Activity, and  2) Autistic Spectrum Disorder: Dynamic Intervention for Neuronal Membrane Stabilization to the January 2009 medical book, Food and Nutrients in Disease Management, edited by a Johns Hopkins University researcher. She has just completed a medical chapter for Dr. John Bach, MD on neurometabolic oral, enteral and parenteral feeding with bioactive lipids for pediatric and adult populations with neuromuscular disease with Drs. Annette Cartaxo and Thomas Wnorowski. Dr. Kane and colleagues are currently writing a book, Membrane Medicine: A NeuroMetabolic Membrane Stabilizing Approach to Neurological Disease.

Dr. Kane is an accomplished lecturer as well as author, presenting to medical societies and universities annually in the US and abroad. In addition, she teaches a 4-day biomedical course to physicians on Membrane Medicine emphasizing targeted lipid therapy and nutritional biochemistry from a cell membrane stabilizing perspective with neurological application several times annually in the US and abroad. She has presented her work to the NIH, Columbia, Johns Hopkins, University of North Carolina at Chapel Hill, University of Kansas, UMDNJ, Eidgenossische Technische (the MIT of Europe), Lipid Mediators in Health and Disease II Symposium, the Royal Medical Society, EuroFed Lipid Congress, Cardiolipin/Barth Syndrome conference, ISSFAL and NORD (Orphan Disease).  Dr. Kane’s innovative work has opened the doors of San Diego Children’s Hospital, Children’s Hospital of Philadelphia, The Cleveland Clinic, Boston Children’s Hospital, Kennedy Krieger Institute, Columbia, UMDNJ, Harvard, Mt. Sinai, and Cornell to neurometabolic lipid pharmacology and Membrane Medicine. Dr. Kane has presented at Grand Rounds at Thomas Jefferson University Hospital Integrative Center and Morristown Atlantic Care Hospital in New Jersey, and to the prestigious Lipid Mediators in Health and Disease organization and the New Jersey Institute for Food, Nutrition & Health.

CEO, BodyBio Inc.

Ed Kane

Edward Kane, born June 6th, 1926, is 90 years young, and  graduated from Temple University in 1947. His fascination with phospholipids has given him the nickname ‘Dances on the Membrane’ as he can visualize the cell membrane and literally dances across it in his mind as he explores the intricacies of the fluid membrane. He has been fascinated with science and medicine for most of his adult life and has closely followed his wife’s work in neurometabolism and lipid biochemistry.

Mr. Kane is the CEO and Chairman of the Board of BodyBio, a biomedical data management company providing medical reports to physicians worldwide. He also serves as President of Neurolipid Research Foundation, a 501(c)3 nonprofit organization in Millville, New Jersey.  A dynamic speaker, Mr. Kane is a marvelous teacher, instructing physicians from a cell membrane perspective four to five times yearly for the  past 20 years.

Mr. Kane’s significant business experience dates back to 1955 when he founded Kane Steel. In 1964 he started K-TRON International the first company to digitize weigh feeding for the process industries. In 1980, he started K-FLOW International to manufacture a patented mass flow meter, a hi-tech, extremely accurate means of measuring fluids for industrial use. In 1998, he started BodyBio to serve international physicians and their patients with biomedical reports and unique lipid supplements that he developed with his wife, Dr. Patricia Kane, PhD, for neurological and genetic/epigenetic disorders.  Mr. Kane holds over 27 US patents and pending patents on instrumentation, nutritional biochemistry and neurological disease.

In 1999, Mr. Kane was honored as one of three “Major Industrialists of the Half Century” as part of the Outstanding Business Persons of the 20th Century selections awarded
by the New Jersey Chamber of Commerce.

Mr. Kane served for 7 years on the Advisory Board of the Foundation for the University of Medicine and Dentistry of New Jersey (UMDNJ) in Stratford, NJ.

Mr. Kane is an instrument rated multi-engine pilot and has twice sailed his yacht across the Atlantic, with only organic, cold pressed essential fatty acids onboard at all times (in the air and at sea).

Internal Medicine Anti-Aging, Regenerative, and Functional Medicine

Dr. Carolyn Matzinger, MD

Dr. Carolyn Matzinger, M.D. has built her career around the premise that the most important aspect of treatment is creating a deep connection with each individual patient. Her style combines cutting edge research and diagnostics in anti-aging medicine with the personal attention missing today in modern medicine. Her passion for healing and personal touch is the embodiment of her work and continues to be at the forefront of her practice.

Dr. Matzinger’s storied career began in 1987 upon receiving her Medical Degree from Wright State University School of Medicine. Completing her Internal Medicine Residency Program in 1990 at the Kettering Medical Center in Kettering, Ohio provided a solid basis for Dr. Matzinger’s study in Internal Medicine followed by Anti-Aging, Regenerative and Functional Medicine. As a Diplomate of both the American Board of Internal Medicine and the American Board of Anti-Aging Medicine, she has worked diligently to be at the forefront of her specialty. She is currently licensed in four states including; Nevada, California, Ohio, and Idaho.

Dr. Matzinger is currently the President and CEO of Private Personal Physician. She is also the Co-Founder of JC Hospitalists, PLLC, an Idaho based Hospitalist Company.

Dr. Matzinger’s extensive training and occupational experience not only uniquely qualifies her to provide services in Internal Medicine and Anti-Aging, Regenerative & Functional Medicine, it is her intrinsic personal character and integrity that redefine the physician’s role, allowing the words “physician” and “caregiver” to be synonymous again.

Dr. Matzinger’s storybook career has been honored numerous times by both her peers and industry thought leaders. In 2005, she was named Physician of the Year, The Golden Stethoscope Award by St. Rose Dominican Hospitals. That same year, she was also honored with the Quarterly Marcus Welby Award. Dr. Matzinger was named one of Las Vegas’ Top Doctors by the Beauty, Health and Fitness Magazine. She is a Lifetime Honoree of the Strathmore’s Who’s Who and a member of America’s Registry of Outstanding Professionals. Recently, Dr. Matzinger co-authored Audacious Aging with other professionals such as Deepak Chopra, and Andrew Weil, which won a silver medal in the Independent Publisher book awards.

A quote by Nelson Mandela summarizes the essence of Dr. Matzinger’s role in both the community and to the lives of her patients. “As we are liberated from our own fear, our presence automatically liberates others.”

 

Virginia Marston, RN, ND

Virginia Marston, RN, ND began her medical career as a registered nurse in Baja, California, transitioning into integrative care in 1992 when her 9-month old daughter, Maria de la Luz, (translation in English ‘Mary of the Light’) suffered severe hypoxia, for which traditional medical care had no viable options.  On February 2, 1993, Dr. Marston met Dr. Patricia Kane, who introduced her to the protocols of membrane stabilizing lipid therapy, to which Mary responded beautifully.  Dr. Marston was catapulted into a variety of medical interventions to assist in her daughter’s care by attending biomedical conferences, by examining the medical literature, and by experiencing hands-on clinical experiences in the United States and abroad.  In short order, Dr. Marston began to help other parents whose children were likewise affected.   Dr. Marston’s greatest teacher was her own daughter, from whom she learned unique approaches to patients suffering neurological anomalies, where tube feedings and intravenous modalities were necessities.  Dr. Marston was invited to present her clinical application of biometabolic therapies at medical conferences.  In 2009 she earned her degree in naturopathic medicine, after which she opened a private clinic, Clinica de la Luz, in Galeana, Chiuhuahua, Mexico to address the needs of patients in an all-inclusive medical setting.   In her clinic, she offers an expansion of therapies often not available in the US or Europe. In 2016, Clinica de la Luz became a hospital, serving both local patients and those visiting internationally with individualized therapy that encompasses the clearance of epigenetic insult with membrane stabilizing therapy.

Environmental & Integrative Medicine

Dr. Damien Downing, MD

Dr. Downing is a specialist in Ecological Medicine, a systems approach to health that considers interactions between the individual and the environment which has 3 components; Allergy, Environment and Nutrition. After qualifying from Guy’s Hospital in 1972, he worked in psychiatry, neuropsychiatry and general practice in the UK, while also studying acupuncture, homeopathy and manipulative therapy. He then spent several years in the Solomon Islands in the Pacific, where his roles included running the Village Health Aid Project and the Mental Health Unit. In 1980 he returned to the UK and established a clinic which developed into Nutrition Associates. He has for 6 years been President of the British Society for Ecological Medicine. He co-founded and was for 20 years Editor of the Journal of Nutritional and Environmental Medicine. He is the author of Daylight Robbery, 1988, about the health benefits of sunlight; co-author of Why ME, 1995; his most recent book, The Vitamin Cure for Allergies, came out in 2010, and The Vitamin Cure for Digestive Disorders will be published soon.

Integrative Medicine

Dr. Tania Dempsey, MD

Dr. Tania Dempsey, MD is a board-certified internist and a diplomat of the American Board of Integrative Holistic Medicine. She received her MD degree from the Johns Hopkins University School of Medicine and her BS degree from Cornell University.  She did her Internal Medicine-Primary Care residency at New York University/Bellevue Hospital. In 2011, after 12 years of practicing medicine within a traditional medical model, she founded Armonk Integrative Medicine (AIM) based on the philosophy of integrating allopathic medicine and complementary therapies. Dr. Dempsey is an expert in chronic diseases, autoimmune disorders and mast cell activation syndrome. She is an accomplished speaker and writer, and her chapter “Chronic Disease and Obesity: The Role of Food Sensitivities” can be found in Anti-Aging Therapeutics, Volume 16, which comprises 22 original chapters authored by the foremost clinical experts in human aging intervention. Dr. Dempsey’s interest in mast cell activation and it’s connection to chronic disease began back in 2013 when she identified her first patient with mast cell activation syndrome (MCAS).  Since then, she has identified that over 75% of her patients have this syndrome.

Understanding how mast cells play a role in many chronic disease states, including pain syndromes, autoimmune diseases, neuropsychiatric disorders and the systematic approach to diagnosis and treatment will be the focus of her presentation.

 

Integrative Medicine

Dr. Kristine Gedroic, MD

Kristine Gedroic received her degree in Biochemistry from Harvard University. She completed her medical degree at Thomas Jefferson University. She began as a resident in plastic surgery at Cornell University in New York City and later switched paths to pursue Integrative Medicine. She completed a Family Practice Residency at Overlook Hospital in New Jersey and then pursued fellowship in Integrative Medicine with Andrew Weil at the University of Arizona. In 2010 she received board certification from the American Board of Medical Acupuncture.

In 2012 Dr. Gedroic opened the Gedroic Center for Integrative Medicine in Morristown, NJ. She has given both Grand Rounds at Morristown Hospital and lectured nationally on various integrative topics. Her approach to care includes primarily naturopathic and homeopathic management of advanced medical conditions. She sees both children and adults at the center. Dr. Gedroic lives in Morristown with her husband and 3 young sons.

Nurse Practitioner

Amy Joy Smith, NP

Amy Joy Smith is a Nurse Practitioner specializing in Functional Medicine at Open Medicine Institute, in Mountain View, California. She is a renowned pioneer in the PANDAS front who does not limit her work to PANS/PANDAS cases, and takes a holistic approach to medicine with experience as a clinical nutritionist. She is also the mother of an amazing child with PANDAS and a dedicated PANDAS awareness advocate.

As a PANDAS parent, Amy understands what it’s like to have your child just slip away one day and have no idea why, to go from doctor to doctor to doctor without answers, to live in a dark place with your sick child, and to lose everything to PANDAS.  Even after all of that, her son, now 20, is a junior in college with a full merit scholarship and a great life ahead of him. She believes that potentially each and every child can heal from PANDAS/PANS with the right information and a huge integrative toolkit.

Amy believes that every aspect of her personal and professional background has led her to this most clinically complex, professionally challenging and humbling work–that of supporting children with PANDAS/PANS and their families, as well as those with Lyme-based infections and other immune illness. She puts everything she has into each patient’s process and is thoroughly committed to seeing an end to the pathetic gap in the diagnosis and proper medical care of children with PANDAS and their families.

Amy serves on the PANDASNetwork.org Board of Directors and was the lead organizer of the West Coast PANDAS/PANS Parent Symposiums in 2012 and 2014. She has spoken at a number of conferences and trainings around the country. Like many providers that see children with PANDAS/PANS, Amy works with patients from around the world.

Having been both the mother of a victim of a long-lasting and oftentimes severe case of PANDAS and a provider since before much was known about the illness, Amy is comfortable interacting with the familial breakdown and personal isolation that stems from it. She takes extra time to address the mental and emotional wellbeing of not only her patients but those affected by them. She makes it clear that people do not have to explain their mental or emotional states to her, or worry that she will judge them or think they’re crazy as many providers less equipped to deal with it often do. Amy knows she never would’ve personally made it through her own son’s illness on an emotional level without the support of other parents just like her. She is honored to be able to give back to these families by helping their children get well.

Known as the ultimate team player, Amy works in tandem with other PANDAS providers around the country and takes the time to reach out to and consult with non-PANS/PANDAS providers who want to learn more about it.

Those who know Amy can see that she assumes a very high level of responsibility for more than just her direct patients.  Although she does have patients in 20 states and seven countries, she takes time out of her incredibly busy life of caring for others to do just that­. For instance, Amy reaches out to connect with other parents through social media and blogging. From time to time she travels to other practices to meet with and train other providers who are entering the realm of PANDAS.  She frequently communicates and works with schools to help them provide the most appropriate services and accommodations to her patients who need them, and last year gave an in-depth training to over 200 school nurses on the east coast on how to identify and support students who may have PANDAS.

Amy has practiced functional and nutritional medicine since the early 1980′s and has studied with a number of pioneers in the field.  She attended Syracuse University School of Nursing where she received her BSN in Maternal-Child Nursing, and all of her acute care and hospital experience is in pediatrics. While currently she is working with all ages of patients, Amy has a passion for working with children and teens.  At the University of Minnesota, she was a Fellow in the World Health Organization’s renowned Adolescent Health Training Program Medical School, and in addition to being a Nurse Practitioner, has a Master’s Degree in Adolescent Health with a focus on Youth Development and Community Health.  She loves educating patients and families and has extensive experience in community education and program development for families as well as vulnerable youth populations.

Amy is passionate about organizing to change public awareness and social policy so people live better lives on every front.  She is on the Board of Directors of PANDASNetwork.org, a parent-based 501(c)(3) nonprofit organization dedicated to promoting PANDAS awareness, research, and advocacy.

 

Developmental Pediatrician

Dr. Annette Cartaxo, MD

Dr. Cartaxo is a board certified pediatrician who is the Vice Chief of Pediatrics at Newton Memorial Hospital in Newton, New Jersey. She is a Developmental/ Behavioral pediatrician who for many years incorporated nutritional medicine in her practice, especially those children with special needs. She is a strong supporter and member of The American College of Nutrition and frequently lectures on the positive impact wholesome nutrition plays on those individuals diagnosed with Autism Spectrum Disorder and Attention Deficit Disorder. She has written several articles in medical text books (Food and Nutrients in disease management) and journals on nutritional medicine.